Epigenetics of Complex Diseases & Traits
Epigenome refers to a set of different chemical modifications to DNA and DNA-associated proteins which regulate gene expression and are heritable. These modifications are part of normal development and tissue differentiation, and can be altered in response to environmental exposures or disease.
Our goal is to assess the contribution of genome and epigenome to obesity and other complex diseases and traits using twin study designs and population-based cohorts. We measure intra-individual epigenetic and phenotypic differences and stability longitudinally in both early life and in early and late adulthood. In addition to human specimens, we use mouse model to get a better insight into causality of tissue specific epigenetic marks associated with complex disease.